Teamwork - differential diagnostics of oxyphilic lesions with groove
Oxyphilic adenoma - Case 3
Papillary carcinoma - Case 67

Oxyphilic cells are located predominantly in compact cell groups. The presence of groove in a great proportion of cells might raise the possibility of a carcinoma although this property has a limited significance in the case of Hürthle-cells.


The high cellularity and the presence of papillary clusters are signs favouring malignancy. Nevertheless the lack of dissociated cells and intranuclear inclusions and grooves argue against the possibility of a carcinoma.


The presence of a halo sign and perinodular blood flow is very specific sign of a follicular tumor. Moreover, the nodule is echonormal which would be an extremely rare presentation of a thyroid carcinoma.

The nodule is hypoechogenic and does not display a halo sign but has perinodular blood flow. These properties favour the possibility of a follicular tumor.

Taking the sonographic and cytological data into account, we gave the diagnosis of a Hürthle-cell tumor.

Taking the sonographic and cytological data into account, we gave the diagnosis of a Hürthle-cell tumor with greater than the average risk of malignancy.

The combination of cytological and sonographic porperties prevented the patient from an unnecessary operation.

The combination of cytological and sonographic porperties led to intraoperative histological examination which resulted in papillary carcinoma. Therefore the patient could be avoided of reoperation.
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