Clinical presentation: A 41-year-old woman was referred for a repeat aspiration cytology of a thyroid nodule known for more than 10 years. At the time of discovery of the lesion aspiration cytology was performed and disclosed benign cystic lesion. Three years before the present examination hyperthyroidism has developed which recurred two-times in the previous years.

Palpation: no abnormality.

Laboratory tests: TSH 0.01 mIU/L, FT4 16.1 pM/L, FT3 7.97 pM/L on daily 20 mg methimazole therapy. TSAb was 11.4 U/L two years ago.

Ultrasonography. The thyroid was hypoechogenic. There was a hypoechogenic nodule having coarse calcification in the central part of the right lobe. The lesion has not increased in size in the past decade.

Cytology resulted in benign cystic-colloid goiter.

Histopathology: goiter corresponding to Graves' disease and benign hyperplastic nodule according to the lesion aspirated.