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Graves' disease - case 799

Nodular goiter

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Right lobe, transverse scan

Right lobe, longitudinal scan

Right lobe, color Doppler mode

Right lobe, microflow imaging

Left lobe, transverse scan

Left lobe, longitudinal scan

Left lobe, color Doppler mode

Summary of ultrasound and laboratory data:

Date of examination

Volume of the thyroid lobes (mL)

Echogenicity index (%)

Therapy before

Results of laboratory investigations

TSAb (U/L) (normal value < 1.5)

Therapy after

Right lobe

Left lobe

TSH (mIU/L)

FT4 (pM/L)

FT3 (pM/L)

7 months after delivery

8.3

6.6
70%

Nothing

0.01

17.7

7.16

1.5

Nothing

9 months after delivery

12.9

12.4

25%

Nothing

< 0.001

51.6

6.90

6.0

20 mg methimazole

11 months after delivery

19.5

15.9

80%

20 mg methimazole

33.7

3.83

-

-

10 mg methimazole

14 months after delivery

11.9

8.7

20%

10 mg methimazole

5.91

12.5

-

-

5 mg methimazole

20 months after delivery

12.8

11.8

15%

5 mg methimazole

2.08

12.6

-

0.1

Nothing

First examination - additional clinical data: A 27-year-old woman was referred for evaluation. She gave birth seven months ago. In the following months, she experienced significant weight loss, sweating, and a high heart rate. Symptoms significantly diminished by the time of the first study.

Second examination - additional clinical data: The patient's previous symptoms recurred two weeks before the study.

Comments.

  1. Based on the clinical symptoms, it is assumed that the patient already had spontaneously improving hyperthyroidism in the months after delivery.

  2. Neither clinical nor hormonal course is characteristic of post partum thyroiditis but is of Graves' disease.

  3. This is the typical course of a Graves' hyperthyroidism which does not relapse within a year. As the hormone result improves, both the size of the initially enlarged goiter and the degree of hypoechogenicity decrease.

 

 

 

 

 

 

 

 

 

 

 

 

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